Assoc Prof Dr. Mazaher Maghsoudloo | Health Professions | Best Researcher Award

Professional Profile 

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Early Academic Pursuits

Mazaher Maghsoudloo embarked on his academic journey in the field of software engineering, earning his B.Sc. from Islamic Azad University in Sari, Iran, in 2003. His passion for computer science led him to pursue an M.Sc. in Computer Science at Shahid Beheshti University in Tehran, where he graduated in 2014. Driven by a keen interest in the intersection of computational methods and biological sciences, he completed his PhD in Bioinformatics from Tehran University, Kish International Campus, in 2020.

Professional Endeavors

Mazaher has held several significant positions throughout his career, reflecting his expertise and dedication to bioinformatics and computational biology. Since 2022, he has been serving in the Department of Genetics, Faculty of Advanced Science and Technology, at Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. He contributed extensively to various research projects at the Laboratory of Systems Biology & Bioinformatics from 2015 to 2022, enhancing the understanding of complex biological systems. His long tenure at The Center of Research and Training for Occupational Technical Safety and Health in Tehran, Iran, from 2008 to 2023, highlights his commitment to integrating bioinformatics with occupational health and safety research.

Contributions and Research Focus

Mazaher’s research interests span a wide array of topics in bioinformatics and computational biology, including cancer biology, molecular biology of diseases, computational systems biology, machine learning, deep learning, and drug repurposing. His notable projects include:

Investigation of gene co-expression networks in chronic lung diseases using a systems biology approach (PhD Thesis) from 2016 to 2020. Genome-wide copy number analysis of circulating tumor cells in breast cancer patients with liver metastasis (Major Cultivation Projects of Achievement Transformation in Sichuan Colleges and Universities) from 2017 to 2020. Comparative mRNA/micro-RNA co-expression network driving melanomagenesis by promoting epithelial–mesenchymal transition and vasculogenic mimicry signaling (supported by the Southwest Medical University, Sichuan Province, China) from 2019 to 2021. Treatment of malignant pleural effusion in non-small cell lung cancer with VEGF-directed therapy (supported by the Southwest Medical University and the Research Foundation of the Science and Technology Department of Sichuan Province) from 2017 to 2020.

Expertise and Teaching

Mazaher is proficient in various programming languages, including R, Python, C#, C++, and C. He has expertise in expression data analysis using microarray and NGS, and he is well-versed in bioinformatics tools such as WGCNA, Limma, DEseq2, EdgeR, Seurat, Scanpy, Cytoscape, Keras, and Graphpad Prism. His knowledge extends to bioinformatics databases, including NCBI, TCGA, Array Express, miRwalk, Enrichr, ToppeGene, DAVID, TRRUST, STRING, DisGeNET, DriverDBv3, GEPIA2, CSCD, circBase, and circinteractome.

In addition to his research, Mazaher has imparted his knowledge through teaching various courses at several institutions. He has taught Digital Logic and Computer Design and Language Programming at the Islamic Azad University, West Tehran Branch, and Computer Application in Management and Software Testing at the Ale-Taha Institute of Higher Education.

Accolades and Recognition

Mazaher’s expertise is recognized through his role as a reviewer for prestigious international journals, including Frontiers in Molecular Biosciences, Frontiers in Immunology, Archives of Gerontology and Geriatrics, BMC Microbiology, Journal of Ophthalmic and Optometric Sciences, and the International Journal of Biophotonics & Biomedical Optics.

Impact and Influence

Mazaher has made significant contributions to the field of bioinformatics and systems biology. His research on gene co-expression networks and cancer biology has provided valuable insights into the molecular mechanisms of diseases. His work on drug repurposing and machine learning applications in bioinformatics has influenced contemporary research approaches and methodologies.

Legacy and Future Contributions

Mazaher’s commitment to advancing bioinformatics and computational biology is evident in his ongoing projects and teaching endeavors. As he continues to explore new frontiers in systems biology and machine learning, his work will undoubtedly leave a lasting impact on the scientific community.

Keynote Speaker

Mazaher’s expertise has been showcased through various keynote speeches. In 2023, he spoke on drug repositioning in non-small cell lung cancer (NSCLC) using systems biology approaches at Farhikhtegan Hospital in Iran. In 2021, he discussed the identification of biomarkers in chronic lung diseases using a systems biology approach at Tabriz Azad University in Iran, and introduced systems biology and bioinformatics at Farhikhtegan Hospital in Iran.

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