Mr. haiyun gan, Shenzhen Institute of Advanced Technolog, China
Dr. Haiyun Gan, born in May 1982 in China, is a distinguished molecular biologist specializing in DNA replication, chromatin biology, and epigenetics. He is currently serving as a Principal Investigator at the Shenzhen Institutes of Advanced Technology. Over the past decade, Dr. Gan has contributed significantly to the understanding of extrachromosomal DNA (ecDNA) and its implications in tumor progression and genome integrity. His academic path includes vital research appointments at Columbia University, Mayo Clinic, and St. Jude Children’s Research Hospital. A recipient of several major research grants, including China's prestigious National Key R&D Program, he leads groundbreaking investigations into artificial chromosomes and histone inheritance. Dr. Gan’s extensive publication record in journals like Cell, Nature Genetics, and PNAS cements his role as a leading voice in genome biology. His lab explores mechanisms that govern DNA replication fidelity and chromatin inheritance, propelling advances in cancer biology and therapeutic strategies.
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Summary of Suitability for the Research for Best Researcher Award – Haiyun Gan
Haiyun Gan’s exceptional contributions to molecular biology and biochemistry position him as a highly suitable candidate for the Research for Best Researcher Award. His diverse and impactful career has led him through prestigious institutions, including the Shenzhen Institutes of Advanced Technology, St. Jude Children’s Research Hospital, Columbia University, and the Mayo Clinic. With a deep expertise in molecular mechanisms, particularly in the inheritance of histones and the relationship between DNA replication and damage in tumors, Gan’s research has shaped our understanding of complex biological processes.
Gan’s leadership in securing significant research grants, including the National Key R&D Program of China (2019-2024) and the NSFC General Project (2021-2024), underscores his ability to direct and manage high-impact scientific projects. His role as a Principal Investigator in these large-scale studies not only speaks to his expertise but also highlights his continued dedication to advancing research in his field. The total funding of over RMB 9 million speaks to the trust and importance the scientific community places on his work.
Education
Dr. Haiyun Gan's academic journey began at Northeast Agricultural University in Harbin, China, where he earned a Bachelor’s degree in Life Sciences (2000–2004). He continued there to obtain a Master’s degree in Microbiology (2004–2007), which sparked his fascination with genetic regulation. His doctoral training at the Chinese Academy of Sciences (2007–2011) in Developmental Biology laid the foundation for his specialization in chromatin biology and epigenetic inheritance. His education was further enriched through postdoctoral research in Biochemistry and Molecular Biology at Mayo Clinic (2012–2016), where he delved into histone dynamics and DNA replication stress responses. These cumulative educational experiences shaped Dr. Gan into a leading investigator in chromatin biology, equipping him with a robust understanding of gene regulation and developmental epigenetics. His scholarly path blends rigorous biological inquiry with innovative molecular techniques, creating a unique perspective in the field of genomic stability and extrachromosomal DNA research.
Professional Experience
Dr. Haiyun Gan currently holds the position of Principal Investigator at the Shenzhen Institutes of Advanced Technology (SIAT), where he has led transformative research since 2019. Prior to this, he worked as a Research Scientist at St. Jude Children’s Research Hospital (2018–2019), focusing on epigenetic regulation in pediatric cancers. From 2016 to 2018, he served as an Associate Research Scientist at Columbia University’s Institute for Cancer Genetics, contributing to vital research on DNA replication and histone inheritance. His early postdoctoral training took place at Mayo Clinic (2012–2016), where he studied chromatin remodeling and replication stress pathways. With over a decade of international research experience across elite institutions in the USA and China, Dr. Gan has amassed a deep expertise in ecDNA biology, chromatin dynamics, and cancer epigenetics. He continues to pioneer work in chromosomal architecture and genome integrity, securing multimillion-yuan funding and publishing in top-tier scientific journals.
Awards and Recognition
Dr. Haiyun Gan has been recognized nationally and internationally for his influential research in the fields of chromatin biology and DNA replication. He currently holds a major five-year grant under the National Key R&D Program of China (2019–2024), where he leads the development of disease models using artificial chromosomes, with funding of RMB 8.6 million. In addition, his NSFC General Project (2021–2024) explores mechanisms of histone transmission and is funded with RMB 540,000. His work has received prominent attention, with papers highlighted in journals such as Nature Genetics, Science, and Cell, demonstrating broad impact across the scientific community. Notably, his research on histone inheritance and ecDNA has been featured by F1000 and recognized in journal editorials. Dr. Gan is a sought-after reviewer and invited speaker at international symposia. His sustained excellence in cancer biology and genome research reflects his status as a leading voice in molecular epigenetics.
Research Skills On ecDNA
Dr. Haiyun Gan possesses advanced expertise in molecular and cellular biology, with a strong specialization in extrachromosomal DNA (ecDNA) dynamics, chromatin remodeling, and epigenetic inheritance. His skill set includes CRISPR/Cas9 genome editing, ChIP-seq, proximity proteomics, and live-cell imaging, allowing precise investigation of histone behavior and DNA replication stress. He is adept at creating disease models using artificial chromosomes and interpreting complex genomic datasets, often leading interdisciplinary collaborations bridging genetics, bioinformatics, and oncology. His lab actively develops innovative tools to label and track histone modifications, enhancing our understanding of cell differentiation and tumorigenesis. His experience spans mouse embryonic stem cells, yeast systems, and cancer cell lines, showcasing versatile model handling. With a keen focus on how chromatin states influence genome integrity, Dr. Gan's research continues to shape emerging therapeutic avenues in cancer treatment. His integrated approach connects molecular mechanics to disease biology, pushing the boundaries of genome research.
Publication Top Notes
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Title: The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
Authors: KM Chan, D Fang, H Gan, R Hashizume, C Yu, M Schroeder, N Gupta, ...
Citation: Genes & Development, 27(9), 985–990
Citations: 736
Year: 2013
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Title: Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
Authors: R Hashizume, N Andor, Y Ihara, R Lerner, H Gan, X Chen, D Fang, ...
Citation: Nature Medicine, 20(12), 1394–1396
Citations: 502
Year: 2014
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Title: A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma
Authors: X Chen, M Zhang, H Gan, H Wang, JH Lee, D Fang, GJ Kitange, L He, ...
Citation: Nature Communications, 9(1), 2949
Citations: 313
Year: 2018
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Title: The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas
Authors: D Fang, H Gan, JH Lee, J Han, Z Wang, SM Riester, L Jin, J Chen, ...
Citation: Science, 352(6291), 1344–1348
Citations: 265
Year: 2016
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Title: A mechanism for preventing asymmetric histone segregation onto replicating DNA strands
Authors: C Yu, H Gan, A Serra-Cardona, L Zhang, S Gan, S Sharma, E Johansson, ...
Citation: Science, 361(6409), 1386–1389
Citations: 241
Year: 2018
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Title: Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis
Authors: H Gan, L Wen, S Liao, X Lin, T Ma, J Liu, C Song, M Wang, C He, C Han, ...
Citation: Nature Communications, 4(1), 1995
Citations: 213
Year: 2013
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Title: Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall
Authors: C Yu, H Gan, J Han, ZX Zhou, S Jia, A Chabes, G Farrugia, T Ordog, ...
Citation: Molecular Cell, 56(4), 551–563
Citations: 210
Year: 2014
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Title: The Mcm2-Ctf4-Polα axis facilitates parental histone H3-H4 transfer to lagging strands
Authors: H Gan, A Serra-Cardona, X Hua, H Zhou, K Labib, C Yu, Z Zhang
Citation: Molecular Cell, 72(1), 140–151.e3
Citations: 183
Year: 2018
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Title: piRNA profiling during specific stages of mouse spermatogenesis
Authors: H Gan, X Lin, Z Zhang, W Zhang, S Liao, L Wang, C Han
Citation: RNA, 17(7), 1191–1203
Citations: 125
Year: 2011
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Title: MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins
Authors: J Chen, T Cai, C Zheng, X Lin, G Wang, S Liao, X Wang, H Gan, D Zhang, ...
Citation: Nucleic Acids Research, 45(7), 4142–4157
Citations: 115
Year: 2017